Multiple drug-resistant HBV mutation may contribute to poor response of adefovir + entecavir in entecavir-resistant patients
نویسندگان
چکیده
منابع مشابه
Treatment response and evolution of HBV resistance during lamivudine plus adefovir or entecavir therapy in patients with adefovir-resistant mutants.
BACKGROUND Here, we investigated the treatment response and evolution of HBV resistance during lamivudine (LAM) plus adefovir (ADV) and entecavir (ETV) monotherapy in patients with ADV-resistant mutants. METHODS Of the 53 patients with ADV-resistant mutants, 25 received combined LAM plus ADV therapy (LAM+ADV group) and 28 received ETV monotherapy (ETV group) for at least 12 months (median 24 ...
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The emergence of entecavir (ETV) resistance is rare, particularly in a longitudinal study. The aim of the present study was to characterize the evolution of ETV-resistant variants during antiviral therapy using entecavir monotherapy followed by ETV-adefovir dipivoxil (ADV) combination therapy. The study included a prospective cohort of 53 consecutive chronic hepatitis B (CHB) patients. During t...
متن کاملEfficacy of Adefovir - based Combination Therapy for Patients with 1 Lamivudine - and Entecavir - Resistant Chronic Hepatitis
Authors: 6 Yun Bin Lee (e-mail: [email protected]) 1 7 Jeong-Hoon Lee (e-mail: [email protected]) 1 8 Won-mook Choi (e-mail: [email protected]) 1 9 Young Youn Cho (e-mail: [email protected]) 1 10 Jeong-ju Yoo (e-mail: [email protected]) 1 11 Minjong Lee (e-mail: [email protected]) 1 12 Dong Hyeon Lee (e-mail: [email protected]) 1 13 Yuri Cho (e-mail: [email protected]) 1 14 Su J...
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A substantial proportion of patients with lamivudine-resistant hepatitis B virus (HBV) show suboptimal virologic response during rescue combination treatment with lamivudine plus adefovir. In this randomized active-control trial, 90 patients with serum HBV DNA levels of >2,000 IU/ml after at least 24 weeks of treatment with lamivudine-plus-adefovir therapy for lamivudine-resistant HBV were rand...
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BACKGROUND/AIMS Before tenofovir (TDF) become available in South Korea, combination therapy with entecavir (ETV) and adefovir (ADV) was the most potent regimen for chronic hepatitis B (CHB) patients who fail to respond to rescue therapy for drug resistance. We analyzed the efficacy of ETV-ADV combination therapy and investigated the clinical and clonal results of TDF-based rescue therapy in CHB...
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ژورنال
عنوان ژورنال: The Journal of Infection in Developing Countries
سال: 2021
ISSN: 1972-2680
DOI: 10.3855/jidc.12643